Kisspeptin-10, human (TFA)

Research use only, not for human use.

Kisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.

Kisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.(In Vitro):Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells.(In Vivo):Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis.

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Others

Other Targets

GPR54

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1416.46

C63H83N17O14.C2HF3O2

>98% (HPLC)

H2O : 4 mg/mL (2.82 mM; Need ultrasonic)

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Sequence:Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

(-20℃)

With Ice Pack

≥ 2 years