Kisspeptin-10, human (TFA)

CAS No.

Kisspeptin-10, human (TFA) ( )

Catalog No. M30044 CAS No.

Kisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Kisspeptin-10, human (TFA)
  • Note
    Research use only, not for human use.
  • Brief Description
    Kisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.
  • Description
    Kisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.(In Vitro):Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells.(In Vivo):Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GPR54
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    1416.5
  • Molecular Formula
    C63H83N17O14.C2HF3O2
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 4 mg/mL (2.82 mM; Need ultrasonic)
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134.
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