Kisspeptin-10, human (TFA)
CAS No.
Kisspeptin-10, human (TFA) ( )
Catalog No. M30044 CAS No.
Kisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameKisspeptin-10, human (TFA)
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NoteResearch use only, not for human use.
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Brief DescriptionKisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.
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DescriptionKisspeptin-10, human TFA, is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10, human TFA inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-gpr54 system plays an important role in embryonic kidney development.(In Vitro):Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells.(In Vivo):Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis.
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Synonyms
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PathwayOthers
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TargetOther Targets
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RecptorGPR54
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight1416.5
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Molecular FormulaC63H83N17O14.C2HF3O2
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Purity>98% (HPLC)
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SolubilityH2O : 4 mg/mL (2.82 mM; Need ultrasonic)
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134.
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